Resources & Support

ONUREG is an oral medicine prescribed by a healthcare provider for adults with AML whose disease is in remission. If you think ONUREG may be right for you, talk to your healthcare team about your treatment options.

Once prescribed, ONUREG is delivered to most patients by a specialty pharmacy.

• Specialty pharmacies handle medications, like ONUREG, that often aren’t stocked at regular neighborhood pharmacies

ONUREG may help you live longer after first remission.* ONUREG is intended to be used until the AML comes back (also called a relapse) or until side effects cannot be managed. Talk to your healthcare team about your specific plan.

* In a clinical trial, people with AML who took ONUREG lived longer overall than people who took placebo (an inactive medicine). Median overall survival was 24.7 months with ONUREG versus 14.8 months with placebo.

For the first two ONUREG cycles (first 2 months), your healthcare team will monitor your blood counts every other week. After the first 2 cycles, your blood counts will be checked prior to the start of every cycle (approximately every month).

• Monitoring may increase to every other week if you experience certain side effects
• You may need to stop treatment (either temporarily or permanently) if you develop certain side effects

ONUREG is an oral medication that can be taken at home, but you will need to visit your healthcare team for follow-up visits and blood work. If you live a far distance away, ask your doctor if there are alternative options such as telemedicine for some appointments.

Ask your healthcare team about the quality of your life and what to expect with ONUREG. Together you can come up with a plan that may help you do the things you enjoy while continuing treatment with ONUREG.

The following list of words and phrases appear throughout this website. Refer to this list if you are reading about AML online or when talking to your healthcare team.

Acute myeloid leukemia (AML): A type of leukemia (or blood cancer) that occurs when blood cells don’t form properly in your bone marrow. Instead, young cells called blasts multiply and crowd out normal healthy cells. This is what causes the symptoms of AML.

Blast (or myeloblast): A young, abnormal, cancerous cell that does not mature into a healthy blood cell in your bone marrow.

Bone marrow: The soft interior of bones where blood cells are created.

Consolidation therapy: A high-dose, intense chemotherapy given after AML is in remission. Not all people receive consolidation therapy.

Continued treatment: A long-term treatment for people not planning to have a transplant. The goal of continued treatment is to kill cancer cells that may be left behind after remission. ONUREG® is a continued treatment.

Neutropenia: Lower-than-normal levels of neutrophils (a type of white blood cell), as measured on a blood test. When you have neutropenia, your body has a harder time fighting infections.

Overall survival: The length of time that a person lives after starting a medication in a clinical trial.

Median overall survival: The length of time after starting a medication in a clinical trial when half the people are still alive.

Placebo: An inactive treatment that resembles a real medicine. Real medicines may be compared to placebos in clinical trials.

Platelet (or thrombocyte): Small cells in your blood that form clots and stop or prevent bleeding.

Remission: The absence of AML signs and symptoms after initial treatment. Being in remission means that less than 5% of your bone marrow contains young, abnormal blood cells (or blasts).

Complete remission: When less than 5% of your bone marrow contains blasts, and all your blood counts are normal.

Complete remission with incomplete blood count recovery: When less than 5% of your bone marrow contains blasts, but some of your blood counts have still not returned to normal.

Thrombocytopenia: Low platelet count on a blood test. Thrombocytopenia can put you at risk for bleeding.

Transplant: An intense procedure that replaces unhealthy stem cells in your bone marrow with healthy cells. Transplant may offer the possibility of a cure for some people with AML.

White blood cell (or leukocyte): A type of blood cell that is part of the body’s immune system. White blood cells protect you against illness and disease.